![]() Red blood cells are made from stem cells in the bone marrow-more specifically, in red bone marrow. But in these cells, beta-globin is not as central to Including cells in the lungs, eyes, and lining of the female reproductive tract. A few other cell types make beta-globin protein (and hemoglobin), Nearly all of the beta-globin in the body is found in red blood cells. The symptoms a person experiences are a result of the combined effects of both alleles. Of the disorder also follow a co-dominant pattern. With some allele combinations-like oxygen transport allele plus sickle cell, or sickle cell allele plus beta-thalassemia-the symptoms Oxygen transport disorders and some forms of beta-thalassemia work this way. A child can inherit the disorder directly from an affected parent. However, in some cases, hemoglobin disorders follow an autosomal dominant inheritance pattern: it takes just one non-working HBB allele Sickle cell disease and most forms of beta-thalassemia work this way. Hemoglobin disorders usually follow an autosomal recessive inheritance pattern: it takes two non-working alleles to cause the disorder, Usually, people with one healthy HBB allele make enough healthy beta-globin protein, and their red blood cells can do their job. Beta-globin proteins are made from bothĪlleles, and they combine randomly to make hemoglobin.
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